منابع مشابه
Sensitivity of BK Channels
Functional large-conductance Ca 2 and voltage-activated K (BK) channels can be assembled from four subunits (Slo1) alone, or together with four auxiliary 1 subunits to greatly increase the apparent Ca 2 sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first, the tail domain of the subunit, which includes the RCK2 (...
متن کاملRINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.
Large-conductance Ca2+- and voltage-activated BK-type K+ channels are expressed abundantly in normal rat pancreatic islet cells and in the clonal rat insulinoma tumor (RINm5f) and hamster insulinoma tumor (HIT) beta cell lines. Previous work has suggested that the Ca2+ sensitivity of BK channels in RIN cells is substantially less than that in HIT cells, perhaps contributing to differences betwe...
متن کاملDo BK channels mediate glioma hypoxia-tolerance?
Like all tumors, human gliomas are remarkably tolerant of hypoxia. Conversely, hypoxia rapidly activates cell death pathways in healthy brain cells. Therapies aimed at reversing the hypoxiatolerance of cancerous cells offer considerable promise in the treatment of brain tumors; however, the underlying cellular mechanisms that permit tumor cells to tolerate prolonged hypoxia are poorly understoo...
متن کاملBK channels in human glioma cells.
Ion channels in inexcitable cells are involved in proliferation and volume regulation. Glioma cells robustly proliferate and undergo shape and volume changes during invasive migration. We investigated ion channel expression in two human glioma cell lines (D54MG and STTG-1). With low [Ca2+]i, both cell types displayed voltage-dependent currents that activated at positive voltages (more than +50 ...
متن کاملSingle-channel kinetics of BK (Slo1) channels
Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts with single-channel current records and progresses to presentation and analysi...
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ژورنال
عنوان ژورنال: Neuron
سال: 2004
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2004.05.017